diff --git a/init/eessi_archdetect.sh b/init/eessi_archdetect.sh
index 4fd979ce..ec22ee22 100755
--- a/init/eessi_archdetect.sh
+++ b/init/eessi_archdetect.sh
@@ -181,6 +181,12 @@ accelpath() {
         nvidia_smi_out=$(mktemp -p /tmp nvidia_smi_out.XXXXX)
         nvidia-smi --query-gpu=gpu_name,count,driver_version,compute_cap --format=csv,noheader 2>&1 > $nvidia_smi_out
         if [[ $? -eq 0 ]]; then
+            if grep -q "Failed to initialize NVML: Driver/library version mismatch" $nvidia_smi_out; then
+                log "ERROR" "accelpath: nvidia-smi command failed with 'Failed to initialize NVML: Driver/library version mismatch'"
+                rm -f $nvidia_smi_out
+                exit 4
+            fi
+
             nvidia_smi_info=$(head -1 $nvidia_smi_out)
             cuda_cc=$(echo $nvidia_smi_info | sed 's/, /,/g' | cut -f4 -d, | sed 's/\.//g')
             log "DEBUG" "accelpath: CUDA compute capability '${cuda_cc}' derived from nvidia-smi output '${nvidia_smi_info}'"